Scientists Sheldon Cooper (Jim Parsons) and Leonard Hofstadter (Johnny Galecki) are as shy as they are genius. When they meet their new neighbor Penny (Kaley Cuoco), they start mustering up the courage to break out of their shell. Their friend Raj Koothrappali (Kunal Nayyar), who is in a similar social dilemma, also figures out a way to talk to women — alcohol. Their other pal Howard Wolowitz (Simon Helberg) seems to be the most confident of them all, but his geeky reactions to everything put him on the spot with the ladies, too.
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