The probe has been barreling toward the dwarf planet and its primary moon, Charon, since January 2006.
On Saturday, an unknown glitch caused New Horizons to switch to a backup computer, which triggered an 81-minute break in radio communications with mission controllers at the Johns Hopkins University Applied Physics Laboratory in Laurel, Maryland, Nasa said in a status report.
"Full recovery is expected to take from one to several days," Nasa said. "New Horizons will be temporarily unable to collect science data during that time."
The work is complicated by the 4-1/2 hours it takes to send a set of signals to the spacecraft, which is nearly 3 billion miles (5 billion km) from Earth.
Like Nasa's early Mariner, Pioneer and Voyager missions that first explored the solar system, New Horizons is designed to conduct science on the fly as it passes within 7,800 miles (12,500 km) of Pluto on July 14.
Pluto's gravity is so weak that it would take a huge amount of fuel for a spacecraft to brake and put itself into orbit.
New Horizons spent most of its nine-year journey to Pluto in hibernation. It was revived in January to begin collecting navigation and science data.
© Thomson Reuters 2015
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